Smirnova T. Yu., Spivak D. L., Yakupova G. S., Zakharchuk A. G., Spivak I. M. Distribution of structural polymorphisms of angiotensin-converting enzyme and serotonin receptor 5-HT2A genes among long-livers of North-Western Russia // Uspekhi Gerontologii [=Successes in Gerontology]. — 2011. Vol. 24. N 4. Pp. 620–625

Distribution of structural polymorphisms of angiotensin-converting enzyme and serotonin receptor 5-HT2A genes among long-livers of North-Western Russia

T. Yu. Smirnova¹, D. L. Spivak², G. S. Yakupova¹, A. G. Zakharchuk³, I. M. Spivak¹

¹ Institute of Cytology, RAS, 4 Tikhoretsky pr., St. Petersburg 194064; ² N. P. Bekhtereva Institute of the Human Brain, RAS, 9, ul. Akad. Pavlova, St. Petersburg, 197376; ³ St. Petersburg State University, 7, Universitetskaya nab., St. Petersburg 199034; e-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it

In the group of long-livers of the North-West of Russia, I/D polymorphism of angiotensin-converting enzyme (ACE) gene and C102T polymorphism of serotonin receptor (5-НТ2А) gene were studied. No reliable differences in allele frequency of these genes between long-livers and young people were detected. Nevertheless, highly pronounced difference in the A1/A2 allele frequency of 5-HT2A gene between populations of the North-West of Russia, on the one hand, and of the USA, on the other hand, was discovered (i.e. 0.397(А1), 0.603(А2), and 0.615(А1), 0.385(А2), respectively). Differences of this kind between the two populations deserve special consideration, conditioning the necessity of further detailed analysis of other genes of the serotonin system in the populations of other regions of Russia.

Key words: serotonin receptor gene (5-НТ2А), long-livers, risk factors for cardiovascular diseases

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